A case report in favor of a multistep adrenocortical tumorigenesis
Identifieur interne : 00B314 ( Main/Exploration ); précédent : 00B313; suivant : 00B315A case report in favor of a multistep adrenocortical tumorigenesis
Auteurs : Marie-Hélène Bernard [France] ; Stan Sidhu [Australie] ; Nicole Berger [France] ; Jean-Louis Peix [France] ; Deborah J. Marsh [Australie] ; Bruce G. Robinson [Australie] ; Véronique Gaston [France] ; Yves Le Bouc [France] ; Christine Gicquel [France]Source :
- The Journal of clinical endocrinology and metabolism [ 0021-972X ] ; 2003.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
Abstract
The mechanisms of adrenocortical tumorigenesis are still not fully understood. Data from clonal analysis, comparative genomic hybridization, and allelotyping suggest that it involves a multistep process during which several genetic defects are progressively acquired, leading to the malignant transformation. The events involved in the first steps of this process are not well known, and most of the abnormalities described in adrenocortical tumors to date are associated with the malignant phenotype. We report a case that suggests that adrenocortical tumorigenesis may be a multistep process. A 43-yr-old patient underwent surgery for an incidentally discovered adrenal mass. Pathological analysis showed that this tumor consisted of two parts: a central part with features of malignancy surrounded by another part with a strictly benign appearance. These data were confirmed by molecular analysis and comparative genomic hybridization that were consistent with either a malignant or benign presentation. The apparently malignant part of the tumor exhibited molecular abnormalities [17p13 loss of heterozygosity (LOH), 11p15 uniparental disomy and overexpression of the IGF-II gene] as well as chromosomal gains and losses (comparative genomic hybridization) that have been previously described in malignant tumors. No abnormalities were found in the surrounding benign tissues. Although this observation is not definitive proof that adrenocortical tumorigenesis occurs via a multistep process, it suggests that there is a progressive change from the benign to the malignant state in some adrenocortical tumors.
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes, Île-de-France
- Lyon, Paris, Sydney
- Université de Sydney
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region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Peix, Jean Louis" sort="Peix, Jean Louis" uniqKey="Peix J" first="Jean-Louis" last="Peix">Jean-Louis Peix</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Service viscérale des Hôpitaux de Lyon</s1><s2>69321 Lyon</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>69321 Lyon</wicri:noRegion><placeName><settlement type="city">Lyon</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Marsh, Deborah J" sort="Marsh, Deborah J" uniqKey="Marsh D" first="Deborah J." last="Marsh">Deborah J. Marsh</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Molecular Medicine, Kolling Institute of Medical Research and University of Sydney, St. Leonards</s1><s2>2065 NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>2065 NSW</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G." last="Robinson">Bruce G. Robinson</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Molecular Medicine, Kolling Institute of Medical Research and University of Sydney, St. Leonards</s1><s2>2065 NSW</s2><s3>AUS</s3><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>2065 NSW</wicri:noRegion><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Gaston, Veronique" sort="Gaston, Veronique" uniqKey="Gaston V" first="Véronique" last="Gaston">Véronique Gaston</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris</s1><s2>75012 Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Le Bouc, Yves" sort="Le Bouc, Yves" uniqKey="Le Bouc Y" first="Yves" last="Le Bouc">Yves Le Bouc</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris</s1><s2>75012 Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Gicquel, Christine" sort="Gicquel, Christine" uniqKey="Gicquel C" first="Christine" last="Gicquel">Christine Gicquel</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, Assistance Publique-Hôpitaux de Paris</s1><s2>75012 Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>75012 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title><title level="j" type="abbreviated">J. clin. endocrinol. metab.</title><idno type="ISSN">0021-972X</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title><title level="j" type="abbreviated">J. clin. endocrinol. metab.</title><idno type="ISSN">0021-972X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal cortex</term><term>Adult</term><term>Carcinogenesis</term><term>Case study</term><term>Comparative genomic hybridization</term><term>Histopathology</term><term>Male</term><term>Malignant transformation</term><term>Molecular biology</term><term>Tumor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Tumeur</term><term>Corticosurrénale</term><term>Transformation maligne</term><term>Etude cas</term><term>Carcinogenèse</term><term>Biologie moléculaire</term><term>Hybridation génomique comparative</term><term>Histopathologie</term><term>Adulte</term><term>Mâle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The mechanisms of adrenocortical tumorigenesis are still not fully understood. Data from clonal analysis, comparative genomic hybridization, and allelotyping suggest that it involves a multistep process during which several genetic defects are progressively acquired, leading to the malignant transformation. The events involved in the first steps of this process are not well known, and most of the abnormalities described in adrenocortical tumors to date are associated with the malignant phenotype. We report a case that suggests that adrenocortical tumorigenesis may be a multistep process. A 43-yr-old patient underwent surgery for an incidentally discovered adrenal mass. Pathological analysis showed that this tumor consisted of two parts: a central part with features of malignancy surrounded by another part with a strictly benign appearance. These data were confirmed by molecular analysis and comparative genomic hybridization that were consistent with either a malignant or benign presentation. The apparently malignant part of the tumor exhibited molecular abnormalities [17p13 loss of heterozygosity (LOH), 11p15 uniparental disomy and overexpression of the IGF-II gene] as well as chromosomal gains and losses (comparative genomic hybridization) that have been previously described in malignant tumors. No abnormalities were found in the surrounding benign tissues. Although this observation is not definitive proof that adrenocortical tumorigenesis occurs via a multistep process, it suggests that there is a progressive change from the benign to the malignant state in some adrenocortical tumors.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li><li>Île-de-France</li></region><settlement><li>Lyon</li><li>Paris</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bernard, Marie Helene" sort="Bernard, Marie Helene" uniqKey="Bernard M" first="Marie-Hélène" last="Bernard">Marie-Hélène Bernard</name></region><name sortKey="Berger, Nicole" sort="Berger, Nicole" uniqKey="Berger N" first="Nicole" last="Berger">Nicole Berger</name><name sortKey="Gaston, Veronique" sort="Gaston, Veronique" uniqKey="Gaston V" first="Véronique" last="Gaston">Véronique Gaston</name><name sortKey="Gicquel, Christine" sort="Gicquel, Christine" uniqKey="Gicquel C" first="Christine" last="Gicquel">Christine Gicquel</name><name sortKey="Le Bouc, Yves" sort="Le Bouc, Yves" uniqKey="Le Bouc Y" first="Yves" last="Le Bouc">Yves Le Bouc</name><name sortKey="Peix, Jean Louis" sort="Peix, Jean Louis" uniqKey="Peix J" first="Jean-Louis" last="Peix">Jean-Louis Peix</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Sidhu, Stan" sort="Sidhu, Stan" uniqKey="Sidhu S" first="Stan" last="Sidhu">Stan Sidhu</name></region><name sortKey="Marsh, Deborah J" sort="Marsh, Deborah J" uniqKey="Marsh D" first="Deborah J." last="Marsh">Deborah J. Marsh</name><name sortKey="Robinson, Bruce G" sort="Robinson, Bruce G" uniqKey="Robinson B" first="Bruce G." last="Robinson">Bruce G. Robinson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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